1 Making Memories 101 When Akira Haraguchi, a retired engineer from Japan, was sixty-nine years old--an age most of us associate with senior discounts and a less-than-optimal memory--he memorized pi, a nonrepeating, infinite number with no pattern, to 111,700 digits. That's the number 3.14159 . . . ​carried out to 111,695 more decimal places. From memory! If this sounds completely mind-blowing, I'm with you. Surely, you're thinking, Haraguchi must have been a child prodigy. Or perhaps he's a mathematical genius or a savant. He's none of these. He's a regular guy with a healthy, aging brain, which means something maybe even more mind-blowing--your brain is also capable of memorizing 111,700 digits of pi. We can learn and remember anything--the unique sound of your child's voice, the face of a new friend, where you parked your car, that time you walked to the market all by yourself to buy sour cream when you were four years old, the words to the latest Taylor Swift song. The average adult has memorized the sound, spelling, and meaning of 20,000 to 100,000 words. Chess masters have memorized in the ballpark of 100,000 possible moves. Concert pianists who can play Rachmaninoff's third concerto have committed the coordination of almost 30,000 notes to memory. And these same folks don't need the sheet music to play Bach, Chopin, or Schumann, either. Our memories can hold information that is deeply meaningful or nonsensical, simple or complex, and its capacity appears to be limitless. We can ask it to remember anything. And under the right conditions, it will. How can memory do all of this? Neurologically speaking, what even is a memory? How is a memory made? Where are memories stored? And how do we retrieve them? Making a memory literally changes your brain. Every memory you have is a result of a lasting physical alteration in your brain in response to what you experienced. You went from not knowing something to knowing something, from never before having experienced today to having lived another day. And to be able to remember tomorrow what happened today means that your brain has to change. How does it change? First, the sensory, emotional, and factual elements of what you experience are perceived through the portals of your senses. You see, hear, smell, taste, and feel. Let's say it's the first evening of summer, and you're at your favorite beach with your best friends and their families. You see, among other things, your children playing soccer on the beach and a spectacular sunset glowing in the sky. You hear "Born This Way," one of your favorite Lady Gaga songs, playing over a portable speaker. Your daughter runs up to you, wailing, pointing to her bright pink ankle. A jellyfish has just stung her. Luckily, your friend carries a small container of meat tenderizer with her for this very scenario. You make a paste of the tenderizer and rub it on the sting, relieving your daughter's pain almost instantly (this really works). You smell the salty ocean air and smoke from the bonfire. You taste crisp, cold white wine, fresh briny oysters, and gooey sweet s'mores. You feel happy. The sight of your children playing soccer has nothing to do with Lady Gaga or jellyfish or the taste of oysters, unless these fleeting, separate experiences become linked. To become a memory that you can later recall--Remember that first night of summer, when we ate oysters and s'mores and listened to Lady Gaga while the kids played soccer on the beach and little Susie Q was stung by a jellyfish?--all that previously unrelated neural activity becomes a connected pattern of neural activity. This pattern then persists through structural changes created between those neurons. The lasting change in neural architecture and connectivity can later be reexperienced--or remembered--through the activation of this now-linked neural circuit. This is memory. Creating a memory takes place in four basic steps: Encoding. Your brain captures the sights, sounds, information, emotion, and meaning of what you perceived and paid attention to and translates all this into neurological language. Consolidation. Your brain links the previously unrelated collection of neural activity into a single pattern of associated connections. Storage. This pattern of activity is maintained over time through persistent structural and chemical changes in those neurons. Retrieval. You can now, through the activation of these associated connections, revisit, recall, know, and recognize what you learned and experienced. All four steps have to work for you to create a long-term memory that can be consciously retrieved. You have to put the information into your brain. You have to weave the information together. You have to store that woven information via stable changes in your brain. And then you have to fetch the woven information when you want to access it. How does a constellation of previously unrelated neural activity become bound together into a connected neural network that we experience as a singular memory? We're not entirely sure of how this happens, but we know a great deal about where it happens. The information contained within an experience that is collected by your brain--the sensory perceptions, the language, the who, what, where, when, and why--is linked by a part of your brain called the hippocampus. The hippocampus, a seahorse-shaped structure deep in the middle of your brain, is essential for memory consolidation. What does that mean? The hippocampus binds your memories. It is your memory weaver. What happened? Where and when did it happen? What does it mean? How did I feel about it? The hippocampus links all these separate pieces of information from disparate parts of the brain together, knitting them into a retrievable unit of associated data, a neural network that, when stimulated, is experienced as a memory. So your hippocampus is necessary for the formation of any new memories that you can later consciously retrieve. If your hippocampus is damaged, your ability to create new memories will be impaired. Alzheimer's disease begins its rampage in the hippocampus. As a result, the first symptoms of this disease are typically forgetting what happened earlier today or what someone just said a few minutes ago and repeating the same story or question over and over. With an impaired hippocampus, people with Alzheimer's have trouble creating new memories. Moreover, the consolidation mediated by the hippocampus is a time-dependent process that can be disrupted. The formation of a memory that can be retrieved tomorrow, next week, or twenty years from now requires a series of molecular events that take time. During that time, if something interferes with the processing of a nascent memory in the hippocampus, the memory can be degraded and possibly lost. Say you're a boxer, a football player, or a soccer player, and you sustain a blow to the head. If I were to interview you immediately after you got clocked, you would be able to tell me about the punch, the play, the details of what was happening. But if I were to ask you the next day, you might have no memory of what happened. The information that was in the process of becoming linked by your hippocampus to form a new, lasting memory was disrupted and was never fully consolidated. The blow to your head caused amnesia. Those memories are gone. Damage to the hippocampus probably explains why Trevor Rees-Jones, bodyguard to Princess Diana and sole survivor of the car crash that killed her and Dodi Fyed all those years ago, still can't remember any details of what happened leading up to the accident. He sustained a devastating head injury, requiring many surgeries and about 150 pieces of titanium to reconstruct his face. Because the various elements of his pre-crash experience had not been fully linked together by his hippocampus when his brain was injured, they were never stored. Those memories of what happened were never made. What happens if you don't have a hippocampus at all? Henry Molaison, or HM, as he is called in the thousands of papers citing his case for over half a century, is the most famous case study in the history of neuroscience. When Henry was a child, he fell off his bicycle, fracturing his skull. Whether because of this head injury or a family history of epilepsy no one is sure, but from the age of ten on, he regularly experienced debilitating seizures. Seventeen years later, his seizures still unrelenting and unresponsive to drug treatment, he was desperate and willing to try anything to get some relief. So on September 1, 1953, at the age of twenty-seven, Henry agreed to undergo experimental brain surgery. The year 1953 was still well within the era of lobotomies and psychosurgeries, procedures that involved the indelicate removal or severing of brain regions to treat mental illnesses such as bipolar disorder and schizophrenia and brain disorders such as epilepsy. These kinds of surgical interventions are deemed grotesque, barbaric, and ineffective today, but back then, they were routinely performed by respected neurosurgeons. With the goal of eliminating Henry's seizures, a neurosurgeon named William Scoville removed the hippocampus and surrounding brain tissue from both sides of Henry's brain. Here's the good news. Henry's seizures almost entirely subsided. And his personality, intelligence, language, motor function, and ability to perceive were undamaged by the procedure. So in that sense, the surgery was a success. But he had tragically traded one plague for another. Excerpted from Remember: The Science of Memory and the Art of Forgetting by Lisa Genova All rights reserved by the original copyright owners. Excerpts are provided for display purposes only and may not be reproduced, reprinted or distributed without the written permission of the publisher.